My default assumption is that Jeffery Epstein committed suicide. However, in the circumstances, anyone who failed to investigate all possibilities would be a complete fool. I like to think I'm not.
What are those possibilities? Obviously foul play is one. The other, however, might encouraged suicide. Government incompetence could play into either one of those scenarios.
Significantly, Undercover Huber is reporting:
Undercover Huber
@JohnWHuber
Reuters has a source telling them Epstein was still on suicide watch as recently as Thursday and procedures to check on Epstein every 30 minutes were not followed overnight 
12:23 PM - 10 Aug 2019
We're also told that video surveillance wasn't operational at the relevant time. However I find the report that Epstein was removed from suicide watch to be important.
The Reuters report--if UC Huber is correct--is contradicted by the NYT, but only as to the timing of Epstein's removal from the suicide watch. The NYT puts the removal at just six days after Epstein's reported suicide attempt on July 29th--although the claim that the previous incident was an actual suicide attempt is disputed. The Daily Mail reports that Epstein told guards weeks before he hanged himself that someone tried to KILL HIM.
One way or another, Epstein was removed from the suicide watch very shortly after being placed on it. That doesn't just happen. According to the NYT: